Proactively shaping the relationship between innovation and work environment  is increasingly determining the success of companies and regions. Innovation, especially in the area of digital transformation, is a key factor for satisfying working conditions and results, social participation and finally the development of entire regions. At the same time, more and more work processes in companies are being geared towards innovation, with the majority of innovations currently being made in the area of digitalization. However, little research has been conducted into the interplay between companies' innovation efforts, working conditions and innovation success (measured by the degree of digitalization, among other things) with regard to these dimensions.  The proposed pilot study therefore examines the current challenges regarding the relationship between innovation dynamics, work and regional change using company data and selected sample regions in Germany. It aims to provide important impulses for understanding the relationship between work and (digital) innovation and thus contribute to the innovation profile of the BMAS. In the course of the project, the project team collects new information using case studies and interviews and also draws on existing data infrastructure like the Mannheim Innovation Panel (MIP) to analyze trends and company activities over the last 20 years.