The aim of this research was to collect data on innovation activities of the business enterprise sector in the State of Berlin in the years 2018 to 2020 as well as the planned innovation activities in 2021 and 2022. For this purpose, the German Innovation Survey 2021 was complemented by a special sample of firms from Berlin. This additional innovation survey for Berlin fully shared all methodical elements of the German Innovation Survey in terms of sampling, questionnaire, survey methodology, data processing and data analysis). Weighted results were reported for the population of enterprises in Berlin with 5 or more employees in manufacturing and business-oriented service sectors and compared to the results for enterprises in other metropolitan regions of Germany.