The aim of this research was to collect data on innovation activities of the business enterprise sector in the State of Brandenburg in the years 2018 to 2020 as well as the planned innovation activities in 2021 and 2022. For this purpose, the German Innovation Survey 2021 was complemented by a special sample of firms from Brandenburg. This additional innovation survey for Brandenburg fully shared all methodical elements of the German Innovation Survey in terms of sampling, questionnaire, survey methodology, data processing and data analysis). The 2021 survey was the second year of surveying innovation activities for the State of Brandenburg, continuing a first project conducted in 2019. Weighted results were reported for the population of enterprises in Brandenburg with 5 or more employees in manufacturing and business-oriented service sectors and compared to the results for enterprises in Germany and the other East German States.